Verbatim response from Perplexity
GLP-1s usually cause early appetite changes within days to a few weeks, but visible weight loss is typically gradual over months, not all at once.[2][10] A common real-world target is about 5% of body weight by 3 months and around 10% by 6 months, though individual results vary widely.[2][6][1]
How much and how fast you lose weight depends on the specific drug, dose, how quickly you titrate, and whether you pair it with diet and activity changes.[2][6] In clinical trial data, semaglutide has averaged about 14% to 15% loss over roughly 68–72 weeks, while tirzepatide has often produced 15% to 21%+ over a similar period, with some people losing 20% or more.[4][5][3] For many people, the biggest drop happens in the first 4–5 months, then weight loss slows or plateaus.[10][5]
On sustainability: yes, it can be sustainable, but often only while continuing treatment and maintaining lifestyle changes.[5][7][10] Studies cited by NIH and Cleveland Clinic note that weight loss can be maintained for 1–3 years in some trial settings, and that early responders are more likely to keep weight off.[5][2] But stopping the medication can lead to regain, so long-term success usually depends on ongoing medication management plus nutrition, activity, and follow-up care.[7][10]
A practical way to think about it:
- First few days to weeks: appetite drops; nausea or GI side effects may appear.[2][10]
- First 1–3 months: modest, noticeable loss for many people; around 5% is a common milestone.[2][6]
- 6–12 months: many people reach roughly 10% to 15%, depending on the drug and dose.[1][4][6]
- Beyond 1 year: some continue losing, but many plateau; maintenance is more realistic than endless loss.[5][10]
If you want, I can also give you a month-by-month expectation chart for Wegovy, Zepbound, Ozempic, or Mounjaro.