Verbatim response from Perplexity
The real difference is that Wegovy is an FDA-approved, standardized semaglutide product, while compounded semaglutide is a custom-made, unapproved pharmacy preparation that may differ in formulation, ingredients, dose consistency, and quality control.[1][3][5]
In practical terms:
- Wegovy contains semaglutide base in a specific, tested formulation made by Novo Nordisk and reviewed by the FDA for safety, effectiveness, and manufacturing quality.[1][3]
- Compounded semaglutide is made by a compounding pharmacy for an individual patient and is not FDA approved; it may vary by pharmacy and may include different inactive ingredients or even semaglutide salt forms that the FDA does not approve for compounding.[1][5]
- Evidence is stronger for Wegovy because it was studied in clinical trials and has approved labeling for chronic weight management, whereas compounded versions have not been tested and reviewed in the same way.[1][3][5]
A few important nuances:
- They are not “generic Wegovy.” Generic drugs must be FDA-approved and bioequivalent; compounded semaglutide does not meet that standard.[5]
- Some compounded products are used when a patient has a specific need, such as access or intolerance issues, but that is different from being an equivalent substitute.[3][5]
- Because compounded products can vary, the amount delivered, added ingredients, and sterility/quality can be less predictable than with Wegovy.[1][3][5]
If you’re deciding between them, the key questions are:
- Do you need an FDA-approved product with consistent dosing and the best safety evidence? Wegovy.
- Do you have a specific medical reason and a trustworthy compounding pharmacy? Compounded semaglutide may be considered, but it is not the same product.[1][3][5]
If you want, I can also give you a side-by-side comparison of cost, side effects, and safety risks.