Progevita

The blood biomarkers that actually matter most for longevity are glucose/HbA1c (blood sugar control), hs-CRP (low-grade inflammation), ApoB (cardiovascular risk), lipid profiles (cholesterol), and kidney/liver function markers like creatinine and ALT/AST. Core Biomarkers for Longevity Category Key Biomarker Why It Matters Optimal Target (if available) Metabolic Health HbA1c & Fasting Glucose High levels increase cardiovascular risk and shorten healthy years; centenarians typically have lower levels starting in their 60s[1][3][4]. HbA1c: <5.4% (often <5.0% for longevity)[3] Inflammation hs-CRP The "classic" marker for chronic, low-grade inflammation ("inflammaging") linked to heart disease, dementia, and mortality[2][3][6]. <1.0 mg/L[3] Cardiovascular Risk ApoB (Apolipoprotein B) More accurate than LDL cholesterol for predicting heart disease risk; reflects the number of harmful lipoprotein particles[2][3][8]. Lower is better (varies by risk profile) Lipid Profile Total Cholesterol, LDL, HDL, Triglycerides Traditional markers for heart disease; centenarians often have higher total cholesterol and iron in the lowest quintile being associated with lower longevity[1][2][6]. Balanced ratios (e.g., high HDL, low LDL) Kidney Function Creatinine High levels indicate reduced kidney function and correlate with lower centenarian probability; however, reduced creatinine in older adults can signal slower kidney decline[1][5]. Age-adjusted normal range Liver Function ALT, AST, Alkaline Phosphatase Elevated liver markers correspond with reduced likelihood of reaching 100; they reflect metabolic stress and organ health[1][2]. Within normal clinical range Inflammation/Metabolism Uric Acid A byproduct of digestion; high levels are linked to inflammation and lower centenarian probability[1]. Lower is generally better How to Interpret These Markers Glucose Control: Centenarians consistently exhibit lower glucose and creatinine levels starting in their sixties, suggesting that strict metabolic control is a lifelong habit[1]. Inflammation is Silent: hs-CRP detects inflammation that doesn't cause obvious symptoms but quietly damages blood vessels over time, making it a critical early warning system[2][8]. ApoB vs. LDL: While traditional lipid panels measure LDL, ApoB is now considered the "most accurate" marker for cardiovascular risk in longevity medicine, as it directly counts the number of atherogenic particles[3][8]. Kidney Nuance: While high creatinine is generally bad, reduced* creatinine in older adults can paradoxically signal a slower decline in kidney function, highlighting the need for age-specific interpretation[5]. Recommended Testing Strategy For a comprehensive longevity assessment, prioritize panels that include: HbA1c and Fasting Glucose (Metabolic) hs-CRP (Inflammation) ApoB and Full Lipid Panel (Cardiovascular) Comprehensive Metabolic Panel (CMP) containing Creatinine, ALT, AST, and Albumin (Kidney/Liver/Nutrition) Brands to consider: Medichecks (offers a dedicated "Longevity Blood Testing" panel with 8 key biomarkers), Progevita (tracks 2026-specific biomarkers including hsCRP and ApoB), and Everlywell (provides panels covering ApoB, HbA1c, and hs-CRP) for accessible, high-quality testing.

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