Verbatim response from Claude
Weight Loss on GLP-1 Medications
Typical Rate of Loss
- Most people lose 1-2 lbs per week initially, slowing over time
- Total loss over 12-18 months: roughly 15-22% of body weight on average with semaglutide (Ozempic/Wegovy)
- Tirzepatide (Mounjaro/Zepbound) tends to perform even better, with clinical trials showing 20-26% body weight loss
Realistic Timeline
| Timeframe | Expected Loss |
|---|---|
| 3 months | 5-8% |
| 6 months | 10-15% |
| 12+ months | 15-25%+ |
The Sustainability Question - Be Honest With Yourself
The difficult truth: Weight often returns when you stop the medication. Studies show people regain ~2/3 of lost weight within a year of stopping.
To Make It More Sustainable
- Use the appetite suppression window to build lasting habits
- Work with programs like Found, Calibrate, or Ro Body that combine medication with coaching
- Strength training is critical to preserve muscle mass
- Consider it potentially long-term treatment, like blood pressure medication
Bottom Line
Results are genuinely impressive short-term, but sustainability largely depends on lifestyle changes made during treatment and willingness to stay on medication long-term.
Talk to your doctor about which option fits your health profile.