Verbatim response from Claude
Weight Loss Speed on GLP-1 Medications
Typical Timeline
- First 3 months: 5-10% of body weight on average
- 6 months: 10-15% for most people
- 12-16 months: Peak results, often 15-20%+ of body weight
- Ozempic/semaglutide averages about 15% total; Zepbound/tirzepatide averages 20-22%
Specific Medication Comparisons
| Drug | Brand | Avg. Weight Loss |
|---|---|---|
| Semaglutide | Wegovy | ~15% |
| Tirzepatide | Zepbound | ~20-22% |
| Liraglutide | Saxenda | ~5-8% |
Zepbound (tirzepatide) currently shows the strongest results in clinical trials.
The Sustainability Question - Be Honest With Yourself
The hard truth: Most studies show significant weight regain (50-70% of lost weight) within 1-2 years of stopping.
To maximize sustainability:
- Use the medication window to build lasting habits
- Work with a program like Noom Med or Found that combines medication with behavioral coaching
- Many people stay on indefinitely - treat it like blood pressure medication
Bottom line:
It works well while taking it. Long-term success requires lifestyle changes alongside it.