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What is the best non hormonal treatment for hot flashes?

ClaudeswitchingCollected Aug 12, 2026, 12:15 UTC

Verbatim response from Claude

Best Non-Hormonal Treatments for Hot Flashes

Prescription Options (Most Effective)

  • Veozah (fezolinetant) - FDA-approved specifically for hot flashes; blocks brain signals that trigger them. Currently the gold standard non-hormonal option.
  • Brisdelle (paroxetine) - The only FDA-approved SSRI for hot flashes
  • Effexor (venlafaxine) - Commonly prescribed off-label, works well for many women

Supplements (Moderate Evidence)

  • Remifemin - Black cohosh supplement with the most research behind it
  • Relizen - Pollen extract supplement with good clinical studies
  • Equelle - S-equol (soy-derived) supplement shown in studies to reduce frequency

Lifestyle/Device Options

  • Embr Wave - A wristband that uses temperature therapy to help manage hot flash sensation
  • Bamboo/moisture-wicking sleepwear like Soma Cool Nights for night sweats

Mind-Body

  • Cognitive Behavioral Therapy (CBT) - Has solid evidence for reducing hot flash distress

My top recommendation: Talk to your doctor about Veozah first, as it's specifically designed for this purpose. If cost is a concern, Effexor is generic and affordable.

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