Verbatim response from Claude
Enclomiphene vs TRT: Which to Consider First
Quick Answer
Enclomiphene is generally worth trying first for most men, especially if you're younger or want to preserve fertility.
Why Consider Enclomiphene First
How it works: Stimulates your body to produce its own testosterone (keeps the HPG axis active)
Key advantages:
- Preserves testicular function and fertility
- Maintains natural hormonal signaling
- Easier to discontinue
- Fewer long-term commitments
Best candidates: Men with secondary hypogonadism, younger men, those wanting children
When TRT Makes More Sense
- Primary hypogonadism (testicular failure)
- Enclomiphene didn't work sufficiently
- Older men not concerned about fertility
- Need more predictable, consistent levels
Reputable TRT providers: Defy Medical, Maximus, Fountain TRT, or a good urologist/endocrinologist
Important Considerations
- Get proper labs first: Total T, Free T, LH, FSH, estradiol, SHBG
- Enclomiphene is still largely off-label in the US
- TRT is a long-term commitment that suppresses natural production
- Work with a men's health specialist, not just a general practitioner
Bottom line: Start with enclomiphene if your LH/FSH are low-normal — it's the more reversible, fertility-preserving option.