Verbatim response from Perplexity
On GLP-1s, many people notice appetite changes and some weight loss within the first 4 weeks, but the more typical pattern is gradual loss over months, not dramatic week-to-week drops.[3] In clinical trials, average weight loss is often about 10%–15% of body weight over roughly 1 year for semaglutide, and about 15%–25% for the most effective GLP-1/GIP options like tirzepatide.[4][5][6]
Whether it is sustainable depends a lot on whether you stay on the medication and keep up lifestyle habits. Studies and expert reviews note that GLP-1s work best as long-term medications, and weight loss can be maintained for 2 years or more in trials while treatment continues.[3][5] When the drug is stopped, weight regain is common, although some people maintain part of the loss, especially if they keep strong nutrition, activity, and follow-up support.[2][3][7]
A practical way to think about it:
- First month: appetite reduction and early loss may begin.[3]
- 3 months: many people have lost around 5%–10%, though responses vary widely.[2]
- 6–12 months: average losses often reach 10%–15% with semaglutide and can be higher with tirzepatide.[4][5][6]
- After stopping: maintenance becomes harder, and some regain is likely without ongoing behavioral changes or another maintenance plan.[3][7]
Results vary a lot by dose, medication, starting weight, diabetes status, and lifestyle support. Real-world data show some people lose little, while others lose 5% or more and a smaller share reach 10%+ without a structured program.[1]
If you want, I can also give you a realistic month-by-month weight-loss timeline for Wegovy, Ozempic, Zepbound, or Mounjaro.