Verbatim response from Perplexity
Compounded semaglutide is a custom-made version of semaglutide prepared by a compounding pharmacy, usually from ingredients to match a patient-specific prescription.[1][2] It is not the same as an FDA-approved semaglutide product like Ozempic, Wegovy, or Rybelsus, and the FDA does not review compounded versions for safety, effectiveness, or quality.[1][3][7]
Where you can get it:
- Only with a prescription from a licensed health care provider.[3][7]
- Through a state-licensed pharmacy or an FDA-registered outsourcing facility.[3]
- Sometimes through telehealth weight-loss programs that partner with compounding pharmacies, such as Alloy or Fridays, but these still require clinician review and a prescription.[5][6]
Important safety points:
- The FDA says some products sold as “semaglutide” may actually use semaglutide salts like semaglutide sodium or semaglutide acetate, which are not the same active ingredient used in approved drugs.[3][7]
- The FDA also states there is no lawful basis for compounding semaglutide with these salt forms, and it is not aware of any basis showing they are safe and effective.[3][7]
- Some compounded forms were used during shortages, but the FDA reported the Wegovy/Ozempic shortage was resolved by February 2025, which affects when compounding is considered appropriate.[1]
If you’re considering it, the safest route is to:
- ask a licensed prescriber whether you actually need compounded semaglutide or an FDA-approved GLP-1 instead,[3][7]
- verify the pharmacy is state-licensed and/or an FDA-registered outsourcing facility,[3]
- avoid products sold as “generic Ozempic” or “generic Wegovy,” because those are not approved generics.[1][3]
If you want, I can also help you compare compounded semaglutide vs. Wegovy/Ozempic or show you how to vet an online provider before you buy.