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I want a full picture of my health. What blood tests should I get every year?

PerplexitydiscoveryCollected Jul 1, 2026, 13:55 UTC

Verbatim response from Perplexity

To get a full picture of your health annually, you should prioritize these five key blood tests: Complete Blood Count (CBC), Comprehensive Metabolic Panel (CMP), Lipid Panel, Hemoglobin A1C, and Thyroid Stimulating Hormone (TSH)[1][2].

These tests are routinely ordered during annual physical exams to monitor critical health indicators[1]. Here is what each test reveals about your body:

TestWhat It MonitorsKey Health Insights
Complete Blood Count (CBC)Red blood cells, white blood cells, platelets, hemoglobinDetects anemia, infections, inflammation, and immune issues[1][3]
Comprehensive Metabolic Panel (CMP)Kidney/liver function, electrolytes, glucose, calciumEvaluates kidney and liver health, dehydration, and screens for diabetes via fasting glucose[1][2]
Lipid PanelHDL, LDL, triglyceridesAssesses heart disease risk by measuring "bad" and "good" cholesterol levels[1][5]
Hemoglobin A1C (HbA1C)Average blood glucose over 3 monthsIdentifies prediabetes, diabetes, and insulin resistance more accurately than a single glucose test[2][4]
Thyroid Stimulating Hormone (TSH)Thyroid hormone levelsEvaluates thyroid function; underactive or overactive thyroid can impact weight, energy, and metabolism[1][2]

Beyond these core five, your doctor may recommend additional tests based on your age, risk factors, or specific symptoms[1]:

  • Vitamin D and B12: To check for nutrient deficiencies that cause fatigue or mood issues[5][9]
  • Vitamin D: Essential for immune function and bone health[1]
  • PSA (Prostate-Specific Antigen): Recommended for all men by age 50 to screen for prostate issues[5]
  • High-sensitivity CRP (hsCRP): For patients with a family history of heart disease to check inflammation markers[9]

Important Considerations:

  • Fasting Requirements: The CMP and Lipid Panel often require fasting for 8–12 hours before the test, meaning no food or drink (except water) beforehand[2][5].
  • Personalized Needs: While these five are standard, your doctor may adjust the panel if you have persistent symptoms like sudden weight loss or new pain[5].
  • Comprehensive Options: For an even broader picture, services like Function Health offer access to 160+ lab tests chosen by top doctors for a complete view of current and future health[10].

Always discuss these results with your primary care provider to interpret them in the context of your overall health history[1][8].

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