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Which blood biomarkers actually matter for longevity?

ClaudediscoveryCollected Jul 14, 2026, 09:42 UTC

Verbatim response from Claude

Key Blood Biomarkers for Longevity

Here are the ones with strong evidence:

Metabolic Health

  • Fasting glucose & insulin (HbA1c) - insulin resistance is a root cause of many diseases
  • Triglycerides/HDL ratio - better cardiovascular predictor than cholesterol alone
  • ApoB - tracks harmful LDL particles more accurately than standard LDL

Inflammation

  • hsCRP (high-sensitivity C-reactive protein) - chronic inflammation marker
  • Homocysteine - linked to heart and brain disease

Organ Function

  • ALT/AST - liver health
  • eGFR/creatinine - kidney function
  • Cystatin C - more accurate kidney marker than creatinine

Hormones & Nutrients

  • Vitamin D - affects immune function, mood, bone health
  • Testosterone/estrogen - decline accelerates aging
  • IGF-1 - growth hormone proxy

Where to Get Tested

  • Function Health (~$500/year) - Peter Attia-backed, tests 100+ biomarkers with physician review
  • LabCorp or Quest - through your doctor, usually insurance-covered
  • InsideTracker - includes personalized recommendations
  • Marek Health - good for hormone-focused panels

Bottom Line

ApoB, fasting insulin, hsCRP, and HbA1c give you the most actionable information per dollar if you're choosing selectively.

Want recommendations on testing frequency or what to do with specific results?

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