Good plan — an annual blood-work “baseline” is a smart way to track health and catch problems early. Below is a concise, practical list of commonly recommended tests for most adults, why each matters, plus additions to consider based on age, sex, or risk factors. I also list labs/services you can use and quick tips on ordering and timing. Core annual tests (most adults) Complete Blood Count (CBC) — screens for anemia, infection, some blood disorders. Comprehensive Metabolic Panel (CMP) or Basic Metabolic Panel (BMP) — checks kidney function (creatinine, eGFR), electrolytes, liver enzymes, and blood glucose (CMP includes liver tests). Lipid panel (fasting or non‑fasting) — total cholesterol, LDL, HDL, triglycerides; cardiovascular risk. Hemoglobin A1c (or fasting glucose) — average blood sugar control; diabetes/prediabetes screening. Thyroid-stimulating hormone (TSH) ± free T4 — screens for hypo- or hyperthyroidism. Vitamin D (25‑hydroxyvitamin D) — common deficiency with wide health effects. Vitamin B12 — neurological/cognitive and anemia risk, especially if you’re older, vegan/vegetarian, or on metformin/PPI. Ferritin (iron stores) — useful if fatigue, heavy menses, or at risk for iron deficiency. Additional useful tests (based on age, sex, or risk) hs‑CRP (high-sensitivity C‑reactive protein) — marker of inflammation and cardiovascular risk. Hepatitis B & C screening — once or as risk dictates (IV drug use, transfusion before 1992, etc.). HIV and syphilis (RPR/treponemal) — if sexually active or new partners/risk factors. PSA (prostate-specific antigen) — discuss with your doctor if a man over ~50 (earlier if African American or family history). Hormone panel (FSH, estradiol, testosterone) — for menopausal symptoms, fertility concerns, or hypogonadism. Iron panel (iron, TIBC) — if ferritin abnormal or symptomatic. Coagulation studies (PT/INR) — only if on anticoagulants or bleeding history. Advanced cardiovascular testing (Lp(a), ApoB) or more frequent lipids — if strong family history of early heart disease. Comprehensive micronutrient panels (magnesium, zinc, folate) — if malabsorption, restrictive diet, or symptoms. How often/when to repeat Most core tests yearly if you’re healthy. More frequent (every 3–6 months) if you have chronic disease (diabetes, liver/kidney disease), abnormal prior results, or are on medications that require monitoring (statins, warfarin, thyroid meds). Practical tips Fasting: lipid panels are often valid non‑fasting, but some clinicians still prefer fasting triglycerides/glucose. Check instructions before your draw. Medication effects: steroids, biotin, and some supplements can affect results — ask your clinician. Interpretation: abnormal results need clinical context; always review results with your primary care provider. Where to get testing (specific providers) Your primary care physician / health system — best for integrated care and follow-up; they can order the right panel and interpret results. Quest Diagnostics or Labcorp — largest national lab networks with many draw sites and insurance acceptance; good if you have a doctor’s order. LetsGetChecked — at‑home sample kits + nurse follow-up; convenient for common panels (lipids, A1c, STI/HIV, thyroid). Everlywell — consumer-friendly at‑home testing for vitamin D, lipids, thyroid, hormones; good for convenience but follow up abnormal results with a clinician. InsideTracker or Thorne Well-Being (Wellness/Wes) — deeper performance/wellness panels with personalized interpretation and lifestyle recommendations (more expensive). Costs and insurance Many tests are covered as part of preventive care under insurance, but coverage varies. Quest and Labcorp accept insurance; direct-to-consumer kits are usually out‑of‑pocket. Always check cost/coverage first. Next step If you want, tell me your age, sex, major medical history (diabetes, heart disease, thyroid disease, medications, family history), and how thorough you want to be (basic vs. comprehensive). I’ll give a tailored annual test list you can print or bring to your clinician.
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