Verbatim response from Perplexity
The best non-hormonal treatment for hot flashes is usually fezolinetant (Veozah), a daily pill that blocks a brain pathway involved in temperature regulation and is specifically approved to treat menopausal hot flashes without hormones.[8] If you want the best studied older option, paroxetine (Brisdelle) is the only non-hormonal medication the FDA has approved for hot flashes, but newer reviews and clinic guidance also support fezolinetant as a leading non-hormonal choice.[8][5]
Other effective non-hormonal prescription options include gabapentin, oxybutynin, and some SSRIs/SNRIs such as venlafaxine or escitalopram.[6][9][4] Among these, gabapentin and oxybutynin have strong evidence for reducing hot flash frequency, while venlafaxine is also widely recommended in reviews.[6][2][3]
If your symptoms are mild, non-drug measures can help: avoid spicy foods, caffeine, alcohol, and use cooling strategies like layered clothing, fans, and lower room temperature.[4][2][8] If you tell me whether your hot flashes are mild, moderate, or severe, and whether you prefer prescription or non-prescription options, I can narrow this to the best choice for your situation.