Verbatim response from Claude
Weight Loss on GLP-1 Medications
Typical Results
- Average loss: 15-22% of body weight over 12-18 months with the most effective options
- Most people lose 1-2 lbs per week in the early months, then it slows
- Results vary significantly by person
Specific Medications (by effectiveness)
- Tirzepatide (Zepbound/Mounjaro) – strongest results, avg ~20-22% body weight loss
- Semaglutide (Wegovy/Ozempic) – avg ~15% body weight loss
- Liraglutide (Saxenda) – older option, avg ~5-8% body weight loss
The Sustainability Problem ⚠️
This is the critical issue:
- Most people regain 50-70% of lost weight within 1-2 years of stopping
- These medications likely need to be taken indefinitely to maintain results
- They work by suppressing appetite, not permanently changing metabolism
What Makes It More Sustainable
- Combining with strength training to preserve muscle
- Working with programs like Calibrate or Found that include lifestyle coaching
- Using the appetite suppression window to build lasting habits
Bottom Line
Results are real but medication-dependent. Think of it more like managing a chronic condition than a one-time fix.
Talk to your doctor about which option fits your health profile.