Verbatim response from Claude
Weight Loss on GLP-1 Medications
Typical Results
- Most people lose 1-2 lbs per week initially, slowing over time
- Semaglutide (Ozempic/Wegovy): Clinical trials show ~15% of body weight over 68 weeks
- Tirzepatide (Mounjaro/Zepbound): Trials show ~20-22% of body weight — currently the strongest option
- Liraglutide (Saxenda): More modest, around ~5-8%
Realistic Timeline
- Weeks 1-4: Modest loss, body adjusting
- Months 2-6: Steepest weight loss phase
- Months 6-12: Gradual slowing as you approach a new set point
The Sustainability Question (Be Honest With Yourself)
Most people regain significant weight if they stop the medication. Studies show ~2/3 of weight returns within a year of stopping.
To maximize sustainability:
- Pair with habit changes (nutrition, strength training)
- Work with a program like Ro, Found, or Sequence (now part of WeightWatchers) that includes coaching
- Consider this potentially long-term or lifelong treatment
Bottom Line
These are powerful tools, but they work best as part of a broader health strategy, not a quick fix.
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