Verbatim response from Claude
Compounded vs. Brand Name Semaglutide
Brand Name Options
- Ozempic (injection, approved for type 2 diabetes)
- Wegovy (injection, approved for weight loss)
- Rybelsus (oral, approved for type 2 diabetes)
These are made by Novo Nordisk and go through rigorous FDA testing for purity, potency, and safety.
Compounded Semaglutide
Pharmacies like Hims & Hers, Henry Meds, and independent compounding pharmacies have offered compounded versions, typically at lower cost.
Key Differences:
| Factor | Brand Name | Compounded |
|---|---|---|
| FDA approved | ✅ Yes | ❌ No |
| Consistent quality | ✅ Verified | ⚠️ Varies by pharmacy |
| Cost | Higher | Lower |
| Insurance coverage | Sometimes | Rarely |
Safety Concerns ⚠️
- The FDA has warned that compounded semaglutide carries real risks
- Some compounders used semaglutide salt (acetate/sodium), which is not bioequivalent
- Quality control varies significantly between pharmacies
- Now that shortages have ended, compounding is largely no longer legally permitted
Bottom Line
Brand name is safer and more reliable. If cost is the barrier, ask your doctor about Novo Nordisk's patient assistance programs or check GoodRx for savings options.