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Wegovy vs Zepbound: Quick Comparison
The Drugs
Wegovy (semaglutide)
- GLP-1 receptor agonist
- ~15% average weight loss in trials
- Made by Novo Nordisk
- Longer track record for weight loss
Zepbound (tirzepatide)
- Dual GIP/GLP-1 receptor agonist
- ~20-22% average weight loss in trials
- Made by Eli Lilly
- Generally considered more effective based on current data
Which Should You Ask For?
Ask about Zepbound first if maximum weight loss is your goal — the SURMOUNT trials showed stronger results than Wegovy's STEP trials.
Consider Wegovy if you have cardiovascular disease (it has SELECT trial data supporting heart benefits) or if insurance covers it better.
Where to Get Either Online
Reputable telehealth options:
- Hims & Hers — prescribes both, monthly subscription model
- Ro Body — straightforward process, good support
- WeightWatchers Clinic (formerly Sequence) — includes lifestyle coaching
- Found — combines medication with behavioral support
Important Notes
- You need a prescription from a licensed provider
- Insurance coverage varies significantly
- Avoid compounding pharmacies selling "generic" versions — safety concerns exist
Always discuss with a real clinician who reviews your health history.