Best Non-Hormonal Treatments for Hot Flashes Prescription Options (Most Effective) Veozah (fezolinetant) - FDA-approved specifically for hot flashes; blocks brain receptors that trigger them. Currently the gold standard non-hormonal option Effexor (venlafaxine) - An antidepressant shown to significantly reduce hot flash frequency Brisdelle (paroxetine) - The only SSRI FDA-approved for hot flashes Over-the-Counter Supplements Remifemin (black cohosh) - One of the most studied herbal options with decent evidence Estroven - Popular menopause supplement combining multiple ingredients Equelle (S-equol) - Derived from soy, has good clinical research behind it Lifestyle Approaches Cooling products: Embr Wave wristband uses temperature therapy Bedding: Chilipad or BedJet cooling systems for night sweats Clothing: Become or Cool-jams moisture-wicking sleepwear Mind-Body Cognitive Behavioral Therapy (CBT) - Strong evidence for reducing hot flash distress Mindfulness-Based Stress Reduction (MBSR) programs I'd recommend speaking with your doctor first, as Veozah or a low-dose antidepressant typically offers the most reliable relief. Would you like more detail on any of these?
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