Best Non-Hormonal Treatments for Hot Flashes Prescription Options (Most Effective) Veozah (fezolinetant) – FDA-approved specifically for hot flashes; blocks brain receptors that trigger them. Currently the gold standard non-hormonal option. Effexor (venlafaxine) – An antidepressant shown to significantly reduce hot flash frequency Brisdelle (paroxetine) – The only FDA-approved SSRI specifically for hot flashes Over-the-Counter Supplements Remifemin (Black Cohosh) – One of the most studied herbal options with reasonable evidence Estroven – Contains black cohosh and other botanicals; popular and widely available NOW Foods Menopause Support – Budget-friendly option with multiple studied ingredients Lifestyle & Cooling Products Embr Wave bracelet – Wearable cooling device that can reduce perceived hot flash intensity Midnight by Luna – Cooling bedding designed specifically for night sweats Important Notes See your doctor before starting any treatment, especially prescription options Results vary significantly between individuals Veozah currently has the strongest clinical evidence among non-hormonal options Would you like more detail on any specific category?
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