Best Non-Hormonal Treatments for Hot Flashes Prescription Options (Most Effective) Veozah (fezolinetant) - FDA-approved specifically for hot flashes; blocks brain receptors that trigger them. Currently the gold standard non-hormonal option. Brisdelle (paroxetine) - The only FDA-approved SSRI for hot flashes Effexor (venlafaxine) - Widely used off-label, well-studied for hot flash relief Supplements (OTC) Remifemin - Black cohosh supplement with the most research behind it Estroven - Popular menopause support blend Bonafide Relizen - Pollen extract with decent clinical backing Lifestyle/Cooling Products Embr Wave - Wristband that uses temperature therapy to reduce hot flash perception Chill Factor cooling towels or Midnight by Hanes cooling pajamas for nighttime symptoms Mind-Body Cognitive Behavioral Therapy (CBT) - Strong evidence; apps like Stella offer menopause-focused support Key Recommendation: Talk to your doctor about Veozah first — it's the newest and most targeted non-hormonal option available. Always consult your healthcare provider before starting any treatment.
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