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How fast will I lose weight on GLP-1s and is it sustainable?

ClaudevalidationCollected Jun 12, 2026, 12:30 UTC

Verbatim response from Claude

Weight Loss on GLP-1 Medications

Typical Speed of Loss

  • First 3 months: Often 5-10% of body weight
  • 6 months: Around 10-15% on average
  • 12-18 months: Up to 15-20%+ for many people
  • Peak results usually come around 12-18 months

Specific Medications to Consider

  • Wegovy (semaglutide) - Clinical trials showed ~15% average body weight loss; strongest evidence
  • Zepbound (tirzepatide) - Currently showing 20-22% average loss, the highest of any approved option
  • Ozempic - Technically diabetes-labeled but widely used; similar results to Wegovy

Is It Sustainable?

Honest answer: It depends on continued use.

  • Studies show people regain most of the weight within 1-2 years of stopping
  • This suggests it may be a long-term or lifelong medication for many people
  • Those who maintain lifestyle changes tend to keep more weight off

Practical Considerations

  • Cost is significant - Wegovy/Zepbound run $1,000-1,300/month without insurance
  • Compounded versions are cheaper but quality varies
  • Hims, Ro, or a bariatric specialist can help with access and monitoring

Talk to your doctor about which option fits your health profile and goals.

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