Verbatim response from Claude
Weight Loss on GLP-1 Medications
Typical Results
- Average loss: 1-2 lbs per week initially, slowing over time
- Total loss: 15-22% of body weight over 12-18 months (with semaglutide/tirzepatide)
- Most people reach a plateau around 12-16 months
Specific Medications to Consider
Wegovy (semaglutide) - ~15% average body weight loss in trials Zepbound (tirzepatide) - ~20-22%, currently the strongest option Ozempic - technically diabetes-focused but widely used off-label
Is It Sustainable?
Honestly, it's complicated:
- ✅ Works well while you're on it
- ⚠️ Studies show most people regain 50-70% of weight within a year of stopping
- The medication essentially needs to be ongoing/lifelong for most people
Practical Recommendations
- Ro, Hims/Hers, or Found are reputable telehealth platforms to get prescriptions
- Use the time on medication to build diet and exercise habits - this improves long-term outcomes significantly
- Discuss with your doctor whether maintenance dosing is an option
The results can be dramatic, but going in with realistic expectations about long-term commitment matters.