Verbatim response from Claude
Compounded Semaglutide vs. Wegovy: Real Differences
What's Actually the Same
- Active ingredient (semaglutide) works identically
- Same mechanism for appetite suppression and blood sugar regulation
- Similar weight loss results when dosed correctly
Real Differences That Matter
Quality & Safety
- Wegovy (Novo Nordisk) undergoes rigorous FDA manufacturing standards
- Compounded versions come from compounding pharmacies with less regulatory oversight — quality can vary significantly between pharmacies
Cost
- Wegovy: ~$1,300-1,400/month without insurance
- Compounded: ~$200-500/month through providers like Hims/Hers, Henry Meds, or LifeMD
Availability
- Compounded semaglutide was legal during the FDA shortage period, but FDA declared the shortage over in 2025, making most compounded versions legally questionable now
Additives
- Some compounders add B12 or other ingredients — not clinically validated combinations
My Honest Recommendation
- If cost isn't a barrier → Wegovy for peace of mind
- If budget is the priority → Use a reputable telehealth provider like Ro or Hims/Hers and ask specifically about their pharmacy sourcing
- Avoid random online vendors — counterfeits are a serious risk
Bottom line: the legal landscape is shifting fast — confirm current regulations before purchasing compounded versions.