Verbatim response from Claude
Compounded Semaglutide vs. Wegovy: Real Differences
What's the Same
- Active ingredient (semaglutide)
- Basic mechanism of action (GLP-1 receptor agonist)
- General weight loss effect
Key Real Differences
Quality & Safety
- Wegovy (Novo Nordisk) undergoes rigorous FDA manufacturing standards, consistency testing, and clinical trials
- Compounded versions come from compounding pharmacies with less regulatory oversight - quality can vary significantly between pharmacies
Legal Status
- Compounded semaglutide was legally allowed during the shortage but the FDA declared the shortage over in 2025, meaning most compounding is now in a legal gray zone
Cost
- Wegovy: ~$1,300-1,500/month without insurance
- Compounded: $200-500/month typically
Reliable Compounding Pharmacies (if you go that route)
- Hims & Hers, BodyLogicMD, Ro - larger platforms with more accountability
- Look for 503B outsourcing facilities which have stricter standards than regular compounding pharmacies
Bottom Line Recommendation
- Choose Wegovy if cost isn't a barrier or you have insurance coverage
- If cost is the issue, use a reputable 503B-affiliated pharmacy and work with a licensed physician
Always consult your doctor before deciding.