Verbatim response from Claude
Weight Loss on GLP-1 Medications
Typical Speed of Loss
- First 3 months: Often 5-10% of body weight
- 6 months: Around 10-15% on average
- 12-18 months: Up to 15-20%+ for some people
- Clinical trials for Wegovy (semaglutide) showed ~15% average body weight loss over 68 weeks
- Zepbound (tirzepatide) showed even stronger results - up to 20-22% in trials
Realistic Expectations
- Loss is gradual (1-2 lbs/week early on, slowing over time)
- Results vary significantly by individual
- Diet and exercise still matter
Sustainability - The Honest Answer
This is the critical issue. Most research shows:
- Weight often returns when medication stops (studies show ~2/3 of weight regained within a year of stopping)
- Many people need long-term or indefinite use
- These are increasingly viewed as chronic condition medications, similar to blood pressure drugs
Getting Started
- Wegovy or Zepbound are the FDA-approved weight-loss versions
- Services like Ro, Hims/Hers, or Noom Med can connect you with prescribers online
- Always consult your doctor about your specific situation
The sustainability question is worth having an honest conversation with your doctor about before starting.