Verbatim response from Claude
Compounded Semaglutide vs. Wegovy: Real Differences
What's the Same
- Active ingredient (semaglutide)
- Basic mechanism of action (GLP-1 receptor agonist)
- General weight loss effect when dosed correctly
Key Real Differences
Quality & Safety
- Wegovy (Novo Nordisk) undergoes rigorous FDA manufacturing standards, clinical trials, and consistent quality control
- Compounded versions are made by individual pharmacies with varying quality standards — some are excellent, some are not
Legal Status
- Compounded semaglutide was only legal during the FDA shortage — now that Wegovy is more available, most compounding is legally questionable or restricted
What You're Actually Getting
- Some compounders use semaglutide salt forms (acetate or sodium) rather than the base form used in Wegovy — not proven equivalent
- Dosing accuracy can vary
Cost
- Compounded: $200-$500/month (significant savings)
- Wegovy: $1,300+/month without insurance
Practical Recommendations
- With good insurance: Get brand-name Wegovy through your doctor
- If cost is the barrier: Use Ro, Hims/Hers, or Found — they navigate insurance and legitimate options
- Avoid random online compounders without verified pharmacy credentials (look for PCAB accreditation)
The FDA shortage exception is largely closing, so act accordingly.