Verbatim response from Claude
Compounded Semaglutide vs. Wegovy: Real Differences
What's Actually the Same
- Active ingredient (semaglutide) works identically in theory
- Same weight loss mechanism (GLP-1 receptor agonist)
Real, Important Differences
Quality & Safety
- Wegovy (Novo Nordisk) is FDA-approved with rigorous manufacturing standards
- Compounded versions come from 503A/503B pharmacies with far less oversight
- Some compounders have had contamination issues and dosing errors - the FDA has issued warnings
What You're Actually Getting
- Compounders often use semaglutide salt forms (acetate or sodium) rather than the base form used in Wegovy - bioequivalence isn't proven
- Wegovy has clinical trial data behind every dose; compounded versions don't
Cost
- Wegovy: ~$1,350/month without insurance
- Compounded: $200-500/month from sources like Hims, Hers, LifeMD, or local med spas
My Honest Recommendation
- Choose Wegovy if covered by insurance or you can afford it
- Reputable compounders like Ro, Hims/Hers, or Henry are reasonable budget options - but verify they use 503B-accredited pharmacies
- Avoid random med spas with no medical oversight
The FDA has signaled compounded semaglutide may be phased out as shortages resolve.