Verbatim response from Claude
Compounded Semaglutide vs. Wegovy: Real Differences
What's Actually the Same
- The active molecule (semaglutide) is identical in theory
- Same basic mechanism of action (GLP-1 receptor agonist)
Key Real Differences
Quality & Consistency
- Wegovy (Novo Nordisk) goes through rigorous FDA manufacturing standards, stability testing, and quality controls
- Compounded versions vary significantly by pharmacy - quality depends heavily on the specific compounder
Regulatory Status
- Wegovy is FDA-approved with proven clinical trial data
- Compounded semaglutide is not FDA-approved and was only legally available during shortage periods - the FDA declared the shortage over in early 2025, meaning most compounders must stop selling it
Additives
- Some compounders add salt forms (semaglutide sodium/acetate) which are chemically different and not proven equivalent
Reputable Compounders (while legal)
- Hims & Hers, Ro, and Amazon Clinic partnered with 503B outsourcing facilities, which have higher standards than typical compounding pharmacies
Bottom Line Recommendation
Wegovy is the safer, more reliable choice if cost isn't prohibitive. Use manufacturer savings programs - Novo Nordisk's savings card can bring it to ~$650/month or less with insurance.
Would you like help navigating the cost options?