Verbatim response from Claude
GLP-1 Weight Loss: What to Expect
Typical Results
- Average loss: 15-20% of body weight over 12-18 months with the most effective options
- Most people lose 1-2 lbs per week early on, slowing over time
- Results vary significantly based on dose, diet, and individual response
Specific Medications (Ranked by Effectiveness)
- Tirzepatide (Zepbound/Mounjaro) – strongest option, avg ~20-22% body weight loss in trials
- Semaglutide (Wegovy/Ozempic) – avg ~15% body weight loss
- Liraglutide (Saxenda) – older, avg ~5-8%, less commonly prescribed now
The Sustainability Question (Be Honest With Yourself)
⚠️ Most people regain weight if they stop – studies show ~2/3 of weight returns within a year of discontinuing
To make it sustainable:
- Treat it as a long-term or permanent medication, not a quick fix
- Use the appetite suppression window to build lasting habits
- Work with programs like Ro, Calibrate, or Found that combine medication with coaching
Where to Get Them
- Hims/Hers, Ro, or your primary care doctor for prescriptions
- Compounded versions are cheaper but face increasing FDA restrictions
The medication works best as a tool, not a solution by itself.