Verbatim response from Claude
Compounded Semaglutide vs. Wegovy: Real Differences
What's Actually the Same
- Active ingredient (semaglutide) works the same way
- Similar weight loss results when dosed correctly
- Same general side effect profile
Real, Important Differences
Quality & Consistency
- Wegovy (Novo Nordisk) undergoes rigorous FDA manufacturing standards, batch testing, and verified purity
- Compounded versions quality varies significantly by pharmacy - some are excellent, some are not
Legal Status
- Compounding was legal during the FDA shortage but the shortage was declared over in early 2025, meaning most compounded semaglutide is now legally restricted
- This is a significant and evolving situation
Cost
- Wegovy: ~$1,300-1,400/month without insurance
- Compounded: $100-400/month - the main appeal
Reliable Compounding Pharmacies (if still legally available)
- Hims & Hers, Ro, and LifeMD used reputable compounding partners
- Look for 503B outsourcing facilities over 503A pharmacies for stricter standards
My Honest Recommendation
If you can afford it or have insurance coverage, Wegovy is the safer, more reliable choice.
If cost is prohibitive, consult your doctor and verify any compounding pharmacy's 503B status and current legal standing before proceeding.
The legal landscape is changing fast - check FDA updates before deciding.