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How fast will I lose weight on GLP-1s and is it sustainable?

ClaudevalidationCollected Jun 30, 2026, 13:23 UTC

Verbatim response from Claude

Weight Loss on GLP-1 Medications

Typical Speed

  • First 3 months: 5-10% of body weight on average
  • 6 months: 10-15% for most people
  • 12-18 months: Up to 15-20%+ with medications like Ozempic/Wegovy (semaglutide) or Mounjaro/Zepbound (tirzepatide)

Tirzepatide tends to produce faster and greater results - clinical trials showed up to 22% body weight loss.

Sustainability - The Honest Answer

While taking the medication: Very sustainable for most people. The appetite suppression is consistent.

If you stop: Most people regain 50-70% of lost weight within a year. This is well-documented.

Practical Recommendations

  • Wegovy (semaglutide) or Zepbound (tirzepatide) are the FDA-approved weight loss versions
  • Use services like Ro, Hims/Hers, or Found for telehealth access if cost is a concern
  • Noom Med combines medication with behavioral coaching, which may improve long-term outcomes
  • Pair with strength training to preserve muscle mass

Bottom Line

These drugs work remarkably well as long as you take them. Think of it more like managing a chronic condition than a temporary fix.

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