Verbatim response from Perplexity
Specific compounded GLP‑1 providers that use licensed U.S. pharmacies include Empower Pharmacy, OrderlyMeds, Henry Meds (via Adonis Health Inc.), and Fridays (though Fridays does not name all partners publicly).
Here’s a breakdown of who they are and how they operate:
| Provider | Licensed U.S. Pharmacy Partners | Notes |
|---|---|---|
| Empower Pharmacy | Operates its own 503A PCAB‑accredited compounding pharmacy (licensed in multiple states) | Ships nationwide, including Puerto Rico; offers compounded semaglutide and tirzepatide [1] |
| OrderlyMeds | Works exclusively with U.S.-based licensed pharmacies: SmartPharmaRx, Casa, PerfectRx/PerfectionRx | All pharmacies are state‑licensed 503A facilities; provides cold‑chain shipping [6] |
| Henry Meds (Adonis Health Inc.) | Uses 503A and 503B compounding pharmacies (specific partners not named on marketing pages) | One of the most transparent providers; mentions its medical group (Colchis Medical Services PC) [3] |
| Fridays | Uses 503A and 503B certified compounding pharmacies; customer reviews mention Beaker Pharmacy as a partner | Does not name all partners publicly; patients can ask support which pharmacy will fill their prescription [3] |
Important regulatory context
- Compounded GLP‑1s (semaglutide, tirzepatide) are not FDA‑approved and are only legally allowed when the commercially available version is in a verified shortage [2].
- As of May 2025, most grace periods for compounded semaglutide and tirzepatide injections have ended; shortages are now resolved, so regular compounding of “essentially copies” of FDA‑approved drugs is no longer permitted except for specific medical needs (e.g., non‑standard doses or forms) [5].
- Compounded semaglutide can currently only come from 503A pharmacies, and a single 503A pharmacy may fill no more than four prescriptions per patient per calendar month [3].
If you’re considering a compounded GLP‑1, confirm with the provider:
- Whether they have a specific medical justification for compounding (e.g., unique dose, allergen removal).
- Which licensed U.S. pharmacy will fill your prescription.
- Whether they comply with the current 4‑prescription/month limit for 503A compounding of semaglutide.
For the most reliable option with a fully licensed U.S. pharmacy under your control, Empower Pharmacy and OrderlyMeds are strong choices because they explicitly name or operate their own licensed facilities and emphasize state compliance.