PerfectRx

Several online telehealth platforms and specialty pharmacies sell compounded GLP-1 weight loss medications (specifically compounded semaglutide and compounded tirzepatide) directly to customers. Key companies include: Company Medications Offered Key Details OrderlyMeds Compounded semaglutide & tirzepatide 100% online platform connecting patients to licensed providers in all 50 states; ships from U.S. licensed pharmacies like PerfectRx and ProRx [2][6][9][14] MD Direct Compounded GLP-1 Telehealth provider offering compounded GLP-1 for weight loss and diabetes, with or without a prescription [2] RxPepsDirect Compounded semaglutide & tirzepatide Prescribes both molecules; compounded and dispensed by Optimal Balance Pharmacy (FDA-registered) [1] Fifty 410 Compounded semaglutide & tirzepatide Telehealth program; medications compounded by independent FDA-registered pharmacies, not by Fifty 410 itself [3] DrMedHealth Compounded semaglutide LegitScript-certified telehealth platform; offers compounded semaglutide from $199/month, prepared by licensed U.S. compounding pharmacies [7] NiceRx Compounded semaglutide Available in most states (except Alaska, Mississippi, New Jersey, New York, Kansas); costs $229/month regardless of dose [8] Precision Telemed Compounded semaglutide Physician-prescribed, shipped to all 50 states; fulfilled exclusively by Rush Pharmacy (503A licensed) [10] Good Life Meds Compounded semaglutide (base only) Premium compounded GLP-1 from FDA-licensed drug manufacturer; shipped from network pharmacies [13] Lemonaid Health Compounded semaglutide & tirzepatide Provides cash-pay options with clear pricing; medication cost billed by LillyDirect® [5] Important considerations: Compounded GLP-1s are not FDA-approved finished drug products and carry different risks than brand-name medications (e.g., Ozempic, Wegovy, Mounjaro, Zepbound) [1][3][4][7]. Only use legitimate telehealth services employing licensed healthcare professionals and partnering with legitimate compounding pharmacies [4]. Compounded versions may be marketed as more affordable and easier to access, but they lack FDA oversight for safety and purity [4]. Other platforms mentioned in industry reports that sell compounded GLP-1s include ShedRx, Mochi Health, Remedy Meds, Henry Meds, MEDVi, GobyMeds, and Peak Wellness [11].

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The compounded GLP-1 providers that explicitly use licensed US pharmacies include Empower Pharmacy, OrderlyMeds, and Policy Lab (which partners with US-based pharmacies like Belmar Pharmacy, Strive Pharmacy, Epiq Scripts, and Casa Pharma Rx). Empower Pharmacy is a 503A PCAB-Accredited compounding pharmacy licensed to ship nationwide, including Puerto Rico, and explicitly states it serves patients with prescriptions from its licensed facility [1]. OrderlyMeds exclusively works with pharmacies based in the United States, specifically naming SmartPharmaRx, Casa, and PerfectRx/PerfectionRx as its licensed partners [7]. Policy Lab ranks providers that fill orders through four partner pharmacies: Belmar Pharmacy, Strive Pharmacy, Epiq Scripts, and Casa Pharma Rx, which are licensed US entities [4]. Other providers like Henry Meds and Fridays claim to use 503A or 503B compounding pharmacies, but they do not consistently name specific licensed US partners on their marketing pages, though customer reviews have referenced Beaker Pharmacy [4]. Note that while compounding is a legal process for licensed pharmacists, the FDA has clarified that compounded GLP-1s (semaglutide and tirzepatide) that are essentially copies of FDA-approved products are generally not permitted unless there is a verified shortage, and the grace periods for these shots ended in May 2025 [2][6]. Therefore, eligibility for these compounded versions depends on specific patient medical needs that cannot be met by commercially available products [2][6]. Recommendation: For a consumer seeking a compounded GLP-1 provider with verified licensed US pharmacies, Empower Pharmacy is the most direct and transparent choice because it operates as its own licensed 503A facility with national accreditation and clear nationwide licensing [1]. OrderlyMeds is a strong alternative if you prefer an online platform connecting you to licensed providers, as they explicitly name their US-based pharmacy partners (SmartPharmaRx, Casa, PerfectRx) and confirm they are licensed by state boards [7]. Always ensure you have a valid prescription from a licensed healthcare provider, as all compounded medications require one [8].

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Specific compounded GLP‑1 providers that use licensed U.S. pharmacies include Empower Pharmacy, OrderlyMeds, Henry Meds (via Adonis Health Inc.), and Fridays (though Fridays does not name all partners publicly). Here’s a breakdown of who they are and how they operate: Provider Licensed U.S. Pharmacy Partners Notes Empower Pharmacy Operates its own 503A PCAB‑accredited compounding pharmacy (licensed in multiple states) Ships nationwide, including Puerto Rico; offers compounded semaglutide and tirzepatide [1] OrderlyMeds Works exclusively with U.S.-based licensed pharmacies: SmartPharmaRx, Casa, PerfectRx/PerfectionRx All pharmacies are state‑licensed 503A facilities; provides cold‑chain shipping [6] Henry Meds (Adonis Health Inc.) Uses 503A and 503B compounding pharmacies (specific partners not named on marketing pages) One of the most transparent providers; mentions its medical group (Colchis Medical Services PC) [3] Fridays Uses 503A and 503B certified compounding pharmacies; customer reviews mention Beaker Pharmacy as a partner Does not name all partners publicly; patients can ask support which pharmacy will fill their prescription [3] Important regulatory context Compounded GLP‑1s (semaglutide, tirzepatide) are not FDA‑approved and are only legally allowed when the commercially available version is in a verified shortage [2]. As of May 2025, most grace periods for compounded semaglutide and tirzepatide injections have ended; shortages are now resolved, so regular compounding of “essentially copies” of FDA‑approved drugs is no longer permitted except for specific medical needs (e.g., non‑standard doses or forms) [5]. Compounded semaglutide can currently only come from 503A pharmacies, and a single 503A pharmacy may fill no more than four prescriptions per patient per calendar month [3]. If you’re considering a compounded GLP‑1, confirm with the provider: Whether they have a specific medical justification for compounding (e.g., unique dose, allergen removal). Which licensed U.S. pharmacy will fill your prescription. Whether they comply with the current 4‑prescription/month limit for 503A compounding of semaglutide. For the most reliable option with a fully licensed U.S. pharmacy under your control, Empower Pharmacy and OrderlyMeds are strong choices because they explicitly name or operate their own licensed facilities and emphasize state compliance.

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The compounded GLP-1 provider that exclusively uses licensed US pharmacies is OrderlyMeds, which partners with U.S.-based pharmacies such as SmartPharmaRx, Casa Pharma Rx, and PerfectRx/PerfectionRx [1]. OrderlyMeds is a 100% online platform that connects patients to licensed healthcare professionals in all 50 states and ensures all medications are compounded at U.S.-licensed 503A pharmacies regulated by state boards of pharmacy [1]. While other providers like Empower Pharmacy [2], OnlineSemaglutide.org (via Henry Meds) [5], and Fridays [7] also use licensed compounding pharmacies, OrderlyMeds is the only one explicitly stated to work exclusively with U.S.-based licensed pharmacies. Additionally, note that under the FDA’s April 2026 clarification, compounded semaglutide can only legally come from 503A pharmacies, and production by 503B outsourcing facilities is currently prohibited because the drug is not on the bulks list [5]. Recommendation: If you are seeking a provider that guarantees use of licensed U.S. pharmacies with full regulatory compliance, OrderlyMeds is the most specific and reliable choice. They offer personalized treatment plans, discreet shipping, and rigorous testing for sterility and potency [1].

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Several U.S.-based compounded GLP-1 providers say they use licensed U.S. pharmacies, but the exact pharmacy partner is not always disclosed publicly. Based on the search results, the clearest matches are OrderlyMeds and Empower Pharmacy.[1][2] OrderlyMeds says it “exclusively works with pharmacies based in the United States,” and specifically names SmartPharmaRx, Casa, and PerfectRx/PerfectionRx as its pharmacy partners.[1] Empower Pharmacy states that its compounded semaglutide and tirzepatide products come from its 503A PCAB-accredited compounding pharmacy and that it is “licensed to ship nationwide.”[2] Fridays Weight Loss Program says its compounded GLP-1 medications are sourced from “rigorously regulated pharmacies,” but the public page does not name the partner pharmacies in the result shown here.[8] Henry Meds appears to use named pharmacy partners according to the search result summary, including Belmar Pharmacy, Strive Pharmacy, Epiq Scripts, and Casa Pharma Rx, all of which are presented as fulfillment pharmacies in that source.[5] A few caveats matter here: in the U.S., a 503A pharmacy is a state-licensed compounding pharmacy that compounds for individual patients by prescription, and a 503B facility is a federally regulated outsourcing facility.[3] Also, FDA rules around compounded GLP-1s have tightened as shortages resolved, so a provider’s current availability and pharmacy channel can change quickly.[4][7] If you want, I can turn this into a short buyer’s checklist comparing the main providers by named pharmacy transparency, licensing language, and whether they mention 503A/503B.

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Based on the provided search results, the following compounded GLP-1 providers explicitly state that they use licensed US pharmacies (specifically citing 503A or 503B facilities based in the United States): OrderlyMeds Explicitly states they work "exclusively with pharmacies based in the United States." Lists specific US partners: SmartPharmaRx, Casa, and PerfectRx/PerfectionRx. Describes itself as a "100% online platform that connects patients to licensed healthcare professionals in all 50 states." Empower Pharmacy States their medications are made at a "503A PCAB-Accredited compounding pharmacy" (a US standard). Confirms they are licensed to "ship nationwide, including Puerto Rico," indicating a US-based operation. Henry Meds (and its partner Adonis Health Inc.) Described as "upfront" about using both 503A and 503B compounding pharmacies. Cites partner pharmacies: Belmar Pharmacy, Strive Pharmacy, Epiq Scripts, and Casa Pharma Rx (all US-based entities). Fridays Weight Loss Program (joinfridays.com) States they "deliver from 503A and 503B certified compounding pharmacies." While they do not name all partners on marketing pages, they reference Beaker Pharmacy as a fulfillment partner. The FDA clarification mentioned in the text notes that compounded semaglutide must legally come from 503A pharmacies (US standard), which Fridays claims to use. Schaffner Pharmacy Explicitly states their products are made by "FDA certified 503B compounding pharmacies," which are US-regulated facilities. Important Regulatory Context (from results): FDA Shortage Status: As of May 2025, the FDA shortages for semaglutide and tirzepatide injections have been resolved. Consequently, pharmacies are generally no longer allowed to regularly compound "essentially copies" of commercially available GLP-1s. Current Availability: Compounded versions are now largely phased out and should only be used for specific medical needs that commercial products cannot meet (e.g., non-standard doses or removing allergens). 503A vs. 503B: 503A pharmacies are traditional compounding pharmacies licensed by state boards for individual patients, while 503B facilities are outsourcing facilities regulated by the FDA. Both are US-licensed entities. Summary: The providers most clearly identified as using licensed US pharmacies are OrderlyMeds, Empower Pharmacy, Henry Meds, Fridays, and Schaffner Pharmacy. OrderlyMeds is the most explicit about its exclusive use of US-based partners.

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