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How fast will I lose weight on GLP-1s and is it sustainable?

ClaudevalidationCollected Jul 15, 2026, 09:33 UTC

Verbatim response from Claude

Weight Loss on GLP-1 Medications

Typical Speed

  • First 3 months: 5-10% of body weight on average
  • 6 months: 10-15% for most people
  • 12-18 months: Up to 15-22% with medications like semaglutide (Ozempic/Wegovy)
  • Tirzepatide (Mounjaro/Zepbound) tends to perform even better, with some trials showing ~20-22% loss

Specific Products to Consider

  • Wegovy (semaglutide) – FDA-approved specifically for weight loss
  • Zepbound (tirzepatide) – newer, often shows stronger results
  • Compounded versions through services like Hims/Hers, Ro, or Found can be more affordable while supplies allow

Is It Sustainable?

Honest answer: It depends on continued use.

  • Studies show most people regain 2/3 of lost weight within a year of stopping
  • It works best as a long-term or lifelong tool, not a short course
  • Sustainable results improve when combined with diet changes and exercise habits built during treatment

Bottom Line

Think of it like blood pressure medication — it works while you take it. The most sustainable approach pairs medication with lasting lifestyle changes so you build habits alongside the appetite suppression.

Talk to your doctor about which option fits your health profile and budget.

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