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You should ask your provider for Zepbound if your primary goal is maximum weight loss (about 20% of body weight vs. 14% for Wegovy), but choose Wegovy if you have established cardiovascular disease, are an adolescent (12–17), or have MASH (fatty liver disease) [1][5][7]. You cannot legally obtain either medication online without a prescription; they are FDA-approved injectable (and pill for Wegovy) prescription drugs that require a doctor’s evaluation and must be obtained through a licensed pharmacy or clinic [2][4][8]. Key Differences to Help You Decide Factor Zepbound (tirzepatide) Wegovy (semaglutide) Mechanism Dual-agonist: GLP-1 + GIP [1][2][5] Single-agonist: GLP-1 only [1][2][5] Weight Loss ~20% of body weight (head-to-head trials) [1][5][6] ~14% of body weight [1][5][6] Cardiovascular Benefit Not approved for CV risk reduction [1][4] Approved to reduce heart attack, stroke, CV death [1][4][5] Age Approval Adults 18+ only [1][5][7] Adolescents 12+ and adults [1][5][7] Liver Disease Not approved for MASH [1][4] Approved for MASH (fatty liver disease with scarring) [1][4] Sleep Apnea Approved to reduce risk of obstructive sleep apnea [1][4][6] Not approved for this [1][4] Form Options Injection only [1][4] Injection + pill form [1][4] Tolerance May be better tolerated if fatigue occurs on Wegovy [1][2] May cause more headaches [1][5] Coverage & Cost Notes Insurance: Wegovy coverage is currently more widely available in commercial and Medicare plans, while Zepbound coverage is narrowing due to some PBMs reducing it [1][5]. Out-of-pocket: Both cost around $1,000/month without insurance, though seniors (65+) may qualify for Zepbound at $50/month under new programs [8][9]. Where to Get Them Legally ✅ Physically: Clinics: PEAK Wellness (VA), Madison MediSpa, Reliable MD, Baptist Health, UCH Health [1][2][3][7][9] Pharmacies: Licensed pharmacies like CVS, Walgreens, or local hospital pharmacies (after prescription) ✅ Online (with prescription): Telehealth services: GoodRx, Buycostmetics, or your provider’s online portal (only if they offer prescription delivery) Mail-order pharmacies: Via your insurance’s partnered mail-service (e.g., OptumRx, CVS Caremark) ❌ Never buy from: Unverified websites, social media sellers, or “online pharmacies” without prescription requirements (high risk of counterfeit or unsafe products) [2][4] Final Recommendation Ask your primary care provider or obesity specialist to evaluate your health history, insurance coverage, and goals before prescribing. They can start you on the most appropriate option and switch if needed [1][2][8].

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