Best Online Treatments for Melasma & Dark Spots Here are the top options across different categories: Prescription Treatments (Most Effective) Curology - Great starting point; a dermatologist prescribes a custom formula often containing tretinoin + niacinamide + azelaic acid. Affordable subscription model. Apostrophe - Similar to Curology but with board-certified dermatologists; can prescribe hydroquinone (the gold standard for melasma). Derrow or Hims/Hers - Also offer prescription topicals for hyperpigmentation. Over-the-Counter Standouts SkinBetter Science Alto Defense Serum - Strong antioxidant formula Paula's Choice 10% Niacinamide Booster - Reduces dark spots affordably Good Molecules Discoloration Correcting Serum - Budget-friendly with tranexamic acid Key Ingredients to Look For Hydroquinone (prescription) Tretinoin/retinoids Tranexamic acid Azelaic acid Vitamin C Niacinamide My Top Recommendation Apostrophe is probably the best online option because melasma specifically responds best to prescription-strength hydroquinone, which requires a doctor. ⚠️ Always use SPF daily — sun exposure worsens melasma significantly.
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