Best Non-Hormonal Treatments for Hot Flashes Prescription Options (Most Effective) Veozah (fezolinetant) - FDA-approved specifically for hot flashes; blocks brain receptors that trigger them. Currently the gold standard non-hormonal option Effexor (venlafaxine) - An antidepressant shown to significantly reduce hot flash frequency Brisdelle (paroxetine) - The only FDA-approved SSRI specifically for hot flashes Over-the-Counter Supplements Remifemin (Black Cohosh) - Well-studied herbal option with decent evidence Estroven - Popular supplement blend containing black cohosh Relizen - Swedish pollen extract with good clinical backing and few side effects Lifestyle Approaches Ebb Insomnia/Cooling products - Cooling devices for night sweats Embr Wave - Wrist cooling device with clinical support Important Notes See your doctor first - prescription options are significantly more effective Results vary person to person Some supplements can interact with medications Veozah is currently considered the most promising new option if you want to avoid hormones entirely, but it requires a prescription. Would you like more details on any specific option?
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