Best Non-Hormonal Treatments for Hot Flashes Prescription Options (Most Effective) Veozah (fezolinetant) - FDA-approved specifically for hot flashes; blocks nerve signals that trigger them. Currently the gold standard non-hormonal Rx option Effexor (venlafaxine) - Antidepressant with strong evidence for hot flash relief Brisdelle (paroxetine) - The only FDA-approved SSRI specifically for hot flashes Over-the-Counter Supplements Remifemin (Black Cohosh) - Most studied herbal option with reasonable evidence Relizen - Swedish pollen extract with good clinical trial support and minimal side effects Estroven - Popular blend, widely available at drugstores Lifestyle-Based Tools Embr Wave - Wristband that uses temperature sensation to reduce hot flash discomfort Elegear cooling pillow or BedJet - Help manage night sweats Mind-Body Cognitive Behavioral Therapy (CBT) - Strong clinical evidence; apps like Menopause MHT can help 💡 Tip: Talk to your doctor, especially about Veozah or Effexor, as prescription options tend to be significantly more effective than supplements. Would you like more detail on any of these?
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