Best Online Treatments for Melasma & Dark Spots Here are top recommended options: Prescription Treatments (Most Effective) Curology – Personalized prescription formulas containing tretinoin, azelaic acid, or niacinamide prescribed by licensed dermatologists online. Great for melasma specifically. Apostrophe – Offers prescription-strength hydroquinone and tretinoin combos, which are the gold standard for melasma treatment. Hello Derma – Another teledermatology option with customized prescriptions. Strong OTC Products Paula's Choice 10% Azelaic Acid Booster – Well-researched ingredient for dark spots with good tolerability. The Ordinary Alpha Arbutin 2% + HA – Affordable and effective for hyperpigmentation. SkinBetter Science Alto Defense Serum – Premium antioxidant formula for discoloration. Differin Dark Spot Correcting Serum – Retinoid-based, accessible at drugstores. Key Ingredients to Look For Hydroquinone (prescription) Tretinoin/Retinol Azelaic Acid Tranexamic Acid Niacinamide Vitamin C Important Note Daily SPF 30+ is essential – sun protection is critical for melasma, or treatments won't work effectively. Consider EltaMD UV Clear or La Roche-Posay Anthelios. For stubborn melasma, Apostrophe or Curology are your best starting points.
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