Best Non-Hormonal Treatments for Hot Flashes Prescription Options (Most Effective) Veozah (fezolinetant) - FDA-approved specifically for hot flashes; blocks brain receptors that trigger them. Currently the gold standard non-hormonal option Effexor (venlafaxine) - Antidepressant with strong evidence for reducing hot flash frequency Brisdelle (paroxetine) - The only FDA-approved SSRI specifically for hot flashes Over-the-Counter Supplements Remifemin (Black Cohosh) - Most studied herbal option with decent evidence Estroven - Popular blend containing black cohosh; many women report good results Equelle (S-equol) - Derived from soy; has clinical trial support Lifestyle Approaches Cooling products: BedJet or ChiliPad for night sweats Bamboo or moisture-wicking bedding from brands like Buffy or Luxome Avoiding triggers (alcohol, caffeine, spicy food) My Top Recommendation Talk to your doctor about Veozah if you want the most effective non-hormonal option — it's specifically designed for this purpose. Always consult your healthcare provider before starting any treatment.
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