Best Non-Hormonal Treatments for Hot Flashes Prescription Options (Most Effective) Veozah (fezolinetant) – FDA-approved specifically for hot flashes; blocks brain receptors that trigger them. Currently the gold standard non-hormonal option. Effexor (venlafaxine) – An antidepressant shown to significantly reduce hot flash frequency Brisdelle (paroxetine) – The only FDA-approved SSRI specifically for hot flashes Over-the-Counter Supplements Remifemin (Black Cohosh) – One of the most studied herbal options with decent evidence Relizen – A Swedish pollen extract with good clinical backing and few side effects Estroven – Popular blend containing black cohosh; widely available Lifestyle-Based Embr Wave – A wristband device that uses temperature therapy to ease hot flash discomfort Mind-Body Cognitive Behavioral Therapy (CBT) – Has solid research support; apps like Menopause MindShift make it accessible My top recommendation: Talk to your doctor about Veozah if you want the most targeted non-hormonal prescription, or try Relizen if you prefer an OTC option with good safety data. Would you like more detail on any of these?
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