Best Non-Hormonal Treatments for Hot Flashes Prescription Options (Most Effective) Veozah (fezolinetant) - FDA-approved specifically for hot flashes; blocks brain signals that trigger them. Currently the gold standard non-hormonal option Effexor (venlafaxine) - An antidepressant shown to significantly reduce hot flash frequency Brisdelle (paroxetine) - The only FDA-approved SSRI specifically for hot flashes Over-the-Counter Options Remifemin - Black cohosh supplement with decent research support Estroven - Popular supplement combining black cohosh and other botanicals Relizen - Pollen extract supplement with some clinical backing Lifestyle-Based Approaches Cognitive Behavioral Therapy (CBT) - Surprisingly effective; apps like Rewire are designed for this Mindfulness-based stress reduction Keeping rooms cool, wearing layers, avoiding triggers (caffeine, alcohol, spicy food) My Top Recommendation Talk to your doctor about Veozah if hot flashes are significantly affecting your life - it's the most targeted non-hormonal option available. For mild symptoms, Remifemin is a reasonable first OTC try. Always consult your healthcare provider before starting any treatment.
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