Best Non-Hormonal Treatments for Hot Flashes Prescription Options (Most Effective) Veozah (fezolinetant) - FDA-approved specifically for hot flashes; blocks brain receptors that trigger them. Currently the gold standard non-hormonal option Effexor (venlafaxine) - Antidepressant with strong evidence for hot flash reduction Brisdelle (paroxetine) - The only FDA-approved SSRI specifically for hot flashes Over-the-Counter Supplements Remifemin (Black Cohosh) - Most studied herbal option with reasonable evidence Estroven - Popular menopause supplement combining multiple ingredients Equelle (S-equol) - Derived from soy isoflavones, good research behind it Lifestyle Approaches Cooling products - Embr Wave wristband uses temperature therapy Bamboo/moisture-wicking bedding - Sheets & Giggles or Ettitude brands Portable fans - Keep one at your desk and bedside Mind-Body Cognitive Behavioral Therapy (CBT) - Strong clinical evidence Paced breathing apps - Headspace or Calm for relaxation techniques ⚠️ Important Note Talk to your doctor first, especially about Veozah or prescription options, as they tend to work significantly better than supplements.
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