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How fast will I lose weight on GLP-1s and is it sustainable?

ClaudevalidationCollected Jun 17, 2026, 13:05 UTC

Verbatim response from Claude

Weight Loss on GLP-1 Medications

Typical Results

  • Most people lose 1-2 lbs per week initially, slowing over time
  • Total loss over 12-18 months:
  • Ozempic/Wegovy (semaglutide): ~15-20% of body weight
  • Mounjaro/Zepbound (tirzepatide): ~20-25% of body weight (currently the strongest option)
  • Saxenda/Victoza (liraglutide): ~5-8% (older, less effective)

Sustainability - The Honest Answer

It's largely medication-dependent, which is important to know:

  • Most people regain 2/3 of lost weight within a year of stopping
  • It works best treated as a long-term or permanent medication, similar to blood pressure drugs

Best Options to Consider

  • Zepbound (tirzepatide) - strongest weight loss results currently
  • Wegovy (semaglutide) - well-established, widely available
  • Ro, Hims/Hers, or Found - telehealth platforms that can prescribe these with good support programs

What Makes Results More Sustainable

  • Combining with strength training to preserve muscle
  • Building dietary habits while on the medication
  • Working with a program like Found or Calibrate that includes coaching

Talk to your doctor about which fits your health profile best.

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