Verbatim response from Claude
Compounded Semaglutide vs. Wegovy: Real Differences
What's Actually the Same
- Active ingredient (semaglutide) works the same way
- Similar weight loss potential when dosed correctly
- Same basic mechanism (GLP-1 receptor agonist)
Real Differences That Matter
Quality & Safety
- Wegovy (Novo Nordisk) is FDA-approved with rigorous manufacturing standards
- Compounded versions come from 503A/503B pharmacies with less oversight - quality can vary significantly
- The FDA has flagged concerns about some compounders using semaglutide salts (acetate/sodium) instead of the base form used in Wegovy
Reliability
- Wegovy has consistent dosing and the auto-injector pen is user-friendly
- Compounded versions require drawing from vials, which introduces dosing error risk
Cost
- Wegovy: ~$1,300-1,500/month without insurance
- Compounded: $100-500/month - the main appeal
Reputable Compounders (if you go that route)
- Hims/Hers, Ro, Mochi Health use licensed 503A pharmacies
- Hallandale Health, Empower Pharmacy are well-regarded 503B facilities
Bottom Line
Wegovy wins on safety and consistency. Compounded makes sense mainly if cost is a barrier - just use a reputable telehealth platform that vets their pharmacy partners.
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