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What is the best online treatment for melasma and dark spots?

ClaudequalifiedCollected Jul 22, 2026, 09:40 UTC

Verbatim response from Claude

Best Online Treatments for Melasma & Dark Spots

Here are the top options worth considering:

Prescription-Strength (Most Effective)

  • Curology – Custom prescription formula containing tretinoin, azelaic acid, or hydroquinone tailored to your skin. Great for stubborn melasma.
  • Agency – Specializes specifically in melasma treatment with dermatologist-prescribed hydroquinone-based formulas.
  • Apostrophe – Online dermatology service offering prescription tretinoin and hydroquinone combinations.

Over-the-Counter Favorites

  • Tranexamic acid serums – Look for Naturium or The Inkey List tranexamic acid serums, which are well-reviewed and affordable.
  • Paula's Choice 10% Azelaic Acid Booster – Clinically proven ingredient for pigmentation without a prescription.
  • Good Genes by Sunday Riley – Lactic acid treatment that brightens effectively.

Key Ingredients to Look For

  • Hydroquinone (prescription)
  • Tretinoin (prescription)
  • Azelaic acid
  • Tranexamic acid
  • Vitamin C
  • Niacinamide

My Top Recommendation

Curology or Agency if you want real results, since melasma typically needs prescription-strength ingredients and professional guidance.

Always pair any treatment with broad-spectrum SPF daily — sun exposure is the #1 trigger for melasma. ☀️

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