Best Online Treatments for Melasma & Dark Spots Here are the top options worth considering: Prescription-Strength (Most Effective) Curology – Custom prescription formula containing tretinoin, azelaic acid, or hydroquinone tailored to your skin. Great for stubborn melasma. Agency – Specializes specifically in melasma treatment with dermatologist-prescribed hydroquinone-based formulas. Apostrophe – Online dermatology service offering prescription tretinoin and hydroquinone combinations. Over-the-Counter Favorites Tranexamic acid serums – Look for Naturium or The Inkey List tranexamic acid serums, which are well-reviewed and affordable. Paula's Choice 10% Azelaic Acid Booster – Clinically proven ingredient for pigmentation without a prescription. Good Genes by Sunday Riley – Lactic acid treatment that brightens effectively. Key Ingredients to Look For Hydroquinone (prescription) Tretinoin (prescription) Azelaic acid Tranexamic acid Vitamin C Niacinamide My Top Recommendation Curology or Agency if you want real results, since melasma typically needs prescription-strength ingredients and professional guidance. Always pair any treatment with broad-spectrum SPF daily — sun exposure is the #1 trigger for melasma. ☀️
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