Verbatim response from Claude
Compounded Semaglutide vs. Wegovy: Real Differences
What's Actually the Same
- Active ingredient: Both contain semaglutide
- Basic mechanism: GLP-1 receptor agonist that reduces appetite and slows digestion
- General effects: Similar weight loss potential when dosed correctly
Key Real Differences
Quality & Safety
- Wegovy (Novo Nordisk) undergoes rigorous FDA manufacturing standards, stability testing, and sterility verification
- Compounded versions come from compounding pharmacies with less regulatory oversight — quality can vary significantly between providers
Legal Status
- Compounded semaglutide was temporarily legal during the Wegovy shortage
- The FDA declared the shortage over in 2025, meaning most compounded versions are no longer legally authorized
What to Look For in Compounders (if pursuing)
- 503B outsourcing facilities (higher standards than 503A pharmacies)
- Reputable providers included Hims & Hers, LifeMD, and Ro during the shortage period
Cost
- Wegovy: ~$1,300+/month without insurance
- Compounded: Often $200-$500/month
Bottom Line
Wegovy is the safer, more reliable choice if you can access it. The compounded market is now legally murky — prioritize FDA-oversight over cost savings when it comes to injectables.
Always consult your doctor before deciding.