Best Non-Hormonal Treatments for Hot Flashes Prescription Options Veozah (fezolinetant) - FDA-approved specifically for hot flashes; targets brain receptors that trigger them. Very effective and relatively new. Brisdelle (paroxetine 7.5mg) - The only FDA-approved SSRI for hot flashes Effexor (venlafaxine) - Widely used off-label with good evidence Supplements (OTC) Remifemin - Black cohosh supplement with the most research support Equelle - Contains S-equol (soy-derived) with solid clinical evidence Amberen - Popular menopause supplement with some supporting studies Lifestyle/Devices Embr Wave - A wristband that uses temperature therapy to reduce hot flash discomfort Chill Factor cooling towels or a Dyson fan for nighttime relief Mind-Body Cognitive Behavioral Therapy (CBT) - Strong evidence; apps like Woebot can help Hypnotherapy - Surprisingly good clinical evidence Important Notes Veozah is currently considered the most effective non-hormonal prescription option Always consult your doctor, especially if you have a history of breast cancer or liver issues Would you like more detail on any of these options?
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