Best Online Treatments for Melasma & Dark Spots Here are the top recommended options: Prescription Treatments (Most Effective) Curology – Customized prescription formulas with ingredients like tretinoin, azelaic acid, and hydroquinone. A dermatologist reviews your skin and tailors a specific blend. Great value around $30-40/month. Apostrophe – Dermatologist-prescribed treatments specifically targeting hyperpigmentation. Known for strong, effective formulas. FaceForward – Another telehealth option offering prescription-strength hyperpigmentation treatments. Over-the-Counter Options Murad Rapid Age Spot Correcting Serum – Contains glycolic acid and hexylresorcinol Paula's Choice 10% Azelaic Acid Booster – Effective and well-tolerated The Ordinary Alpha Arbutin 2% + HA – Affordable and well-reviewed SkinCeuticals Discoloration Defense – Dermatologist-favorite with tranexamic acid Key Ingredients to Look For Hydroquinone (prescription) Tretinoin/retinoids Tranexamic acid Azelaic acid Vitamin C Kojic acid My Top Pick Curology is arguably the best starting point because melasma often requires prescription-strength ingredients and a personalized approach rather than guessing with OTC products. Always pair any treatment with SPF 30+ sunscreen daily — sun protection is essential for melasma treatment to work.
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